詢 價
索取COA
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫
Introduction | |
Description | 滋養(yǎng)層細胞表面抗原2(Trophoblast cell sur-face antigen 2, Trop2)是由染色體1p32上的基因腫瘤相關(guān)鈣通道傳感蛋白2(tumor-associated calcium signal transducer 2, TACSTD2)編碼的36 kDa跨膜蛋白。研究表明,Trop2在多種實體瘤中高表達,包括胃癌(Gastric cancer, GC)、乳腺癌(Breast cancer, BC)和宮頸癌(Cervical cancer, CC)等,其能通過參與多種細胞內(nèi)信號通路,例如絲裂原活化蛋白激酶(Mitogen-activated protein kinases, MA-PKs)和磷脂酰肌醇3-激酶(Phospoinositide 3-kin-ases, PI3K)等信號通路,從而促進腫瘤細胞的增殖、遷移和侵襲。因其在實體瘤中高表達且與患者預(yù)后不良顯著相關(guān),Trop2已經(jīng)成為癌癥治療非常有潛力的靶點。 |
Technical Data | |
切片厚度 | 5 μm |
IHC染色結(jié)果 | |
|
|
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1片/張 |
Storage | -25~ -15℃ |
Expiry | 36 months from the date of manufacture |