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TP53 p.D281G Reference Standard

CBP10210

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Introduction 
Format Genomic DNA
Description TP53 D281G lies within the DNA interaction domain of the Tp53 protein (UniProt.org). The functional effect of D281G is conflicting, as it has been reported to decrease transactivation of wild-type Tp53 targets and also confers a gain of function to Tp53, which leads to aberrant gene transcription and cell migration (PMID: 22114072).
   
Technical Data 
DNA Change c.842A>G
AA Change p.D281G
Mutation type Substitution - Missense
Zygosity Homozygous
Allelic Frequency 100%
Transcript ENST00000269305
Cosmic ID COSM11232
Chr position(GRCh37) chr17:7577096
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing Download for COA
Storage 2-8
Expiry 36 months from the date of manufacture

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