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產(chǎn)品描述
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Introduction | |
Format | Genomic DNA |
Description | TP53 D281G lies within the DNA interaction domain of the Tp53 protein (UniProt.org). The functional effect of D281G is conflicting, as it has been reported to decrease transactivation of wild-type Tp53 targets and also confers a gain of function to Tp53, which leads to aberrant gene transcription and cell migration (PMID: 22114072). |
Technical Data | |
DNA Change | c.842A>G |
AA Change | p.D281G |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Transcript | ENST00000269305 |
Cosmic ID | COSM11232 |
Chr position(GRCh37) | chr17:7577096 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | Download for COA |
Storage | 2-8℃ |
Expiry | 36 months from the date of manufacture |